UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 2 / Published : 2014-04

Order : 6, and page :92 - 95

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Original Article :

Correlation between tgf-1 plasma level and cd4+ t lymphocyte count in stage i hiv-infected patients

Author :

  1. Alberthina Suripatty*1
  2. Endang Retnowati*2
  3. Erwin Astha Triyono*3
  4. Windhu Purnomo*4
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran
  4. Dosen Fakultas Kesehatan Masyarakat

Abstract :

HIV infection and AIDS have spread throughout the world and the number of patients continues to increase from year to year.Indonesia is one of the countries with a quite high increase in incidence of HIV and AIDS. The absolute number of CD4+Tlymphocytesand percentage in HIV-infected patients can be used to determine the stage of disease, progression of the disease, and topredict the onset of opportunistic diseases. Sometimes it is difficult to determine clinically in certain circumstances and the results ofthe absolute number of CD4+ T-lymphocytes and percentage are still high so examination of TGF1 is necessary to predict thecourse of the disease in the patient, because the increase in disease progression is also accompanied by increased levels ofTGF1.This was a cross sectional observational study, the samples consisted of 41 stage I HIV-infected patients treated in theOutpatient Clinic of the Infectious Disease Intermediate Care Unit (UPIPI) Dr. Soetomo Hospital from January to May 2012.Examination of TGF1 plasma was performed by ELISA method, the number of absolute and percentage CD4+T-lymphocyte byusing flowcytometry (BD FACSCalibur™). The results were statistically analyzed using a Pearson product moment correlationtest.mThe result of the number of CD4+T-lymphocytes of less absolute and more than 200 cells /L shows no correlation withplasma levels of TGF1 in stage I HIV infection patients. There is a significant positive correlation between the number of CD4+Tlymphocytespercentage with TGF1 plasma in stage I HIV infection.(FMI 2014;50:92-95)

Keyword :

TGF- plasma levels, CD4+T-lymphocytes, stage I HIV Infection,


References :

Abbas AK and Lichtman AH,(2010) Basic Immunology Functions and Disorders of The Immune System,3rd ed. Philadelphia : WB Saunders

Alimonti JB, Ball TB, Fowke KR,(2003) Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS - : J Gen Virol





Archive Article

Cover Media Content

Volume : 50 / No. : 2 / Pub. : 2014-04
  1. The effect of 3000 mg intravenous vitamin c on serum nitric oxide level of severe burnt injury patients
  2. Correlation between plasma levels of interferon and viral load in patients with hiv stage 1
  3. Correlation between serum level of heart type fatty acid binding protein (h-fabp) and n-terminal pro-brain natriuretic peptide (nt-probnp) on acute coronary syndrome patient
  4. Profile of gyra and gyrb gene mutation in clinical isolate of ciprofloxacin resistant pseudomonas aeruginosa
  5. Effect of cardiac rehabilitation programs on functional capacity of post coronary revascularization patient using six minute walk-test
  6. Correlation between tgf-1 plasma level and cd4+ t lymphocyte count in stage i hiv-infected patients
  7. The effect of 3000 mg vitamin c infusion on histamine level of severely burnt patients
  8. Comparison of fugl-meyer score between patients with acute thrombotic infarc stroke treated with standard medication and fluoxetine
  9. Antibiotics quantity-based escherichia coli resistance pattern in patients at surgical and psychiatric wards, dr soetomo hospital, surabaya
  10. Age and resting heart rate are discriminators to predict endurance without physical test
  11. Case report: trunk and reticular varicose on a 9-year-old child
  12. Comparison of the apgar score of spontaneous vaginal birth and assisted birth in dr. soetomo hospital surabaya
  13. Five years retrospective study of burns in dr soetomo general hospital surabaya

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